
Well, getting ready for bed and this came up in my email.


Whoa boy does she ever go off on a really weird tangent with this.
Not only that, but she also quotes Mr. Brainworm himself:


But it’s not just Jane that goes off into absurdity, it’s the responses to her post that are off their ever loving rockers as well.

You gotta shake it and use a plunger to get that stuck spirit outta the body.

Use a sink plunger and not a closet plunger
The closet plunger might have dookie on it.




Midazolam:
First off, if Midazolam was as ineffective as she seems to be claiming it is, then why aren’t there thousands of cases of patients waking up from surgery completely traumatized because they remember being cut open and having the doctors working inside? The typical dosage for surgery is 0.03 mg / kg of body weight. A person weighing 80 kg would receive 2.4 mg. The protocol for MAiD calls for an injection of 10 mg.
🧠 Primary Target: Central Nervous System (CNS)
Midazolam enhances GABA-A receptor activity (an inhibitory neurotransmitter), leading to widespread CNS suppression.
💭 1. Brain
- Cerebral Cortex: Reduces anxiety, impairs awareness, causes sedation
- Hippocampus: Causes anterograde amnesia (can’t form new memories)
- Amygdala: Reduces fear and emotional tension
- Thalamus: Diminishes sensory processing
- Brainstem: Suppresses reflexes (e.g., gag reflex in high doses)
- Reticular Activating System (RAS): Induces sleep-like state
🫁 Respiratory System
- Depresses respiratory drive by affecting medullary centers
- In higher doses (especially when combined with opioids or propofol), can cause:
- Hypoventilation
- Apnea
- Oxygen desaturation
❤️ Cardiovascular System
- Mild blood pressure reduction due to central vasodilation
- Bradycardia in some cases (more common when used with other sedatives)
⚠️ What Midazolam Does Not Do:
- No direct analgesic (pain relief) effect
- Does not paralyze muscles (unlike rocuronium)
- Does not affect the heart muscle directly
🕒 Onset and Duration:
- IV onset: ~1–5 minutes
- IM onset: ~15 minutes
- Half-life: ~1.5–3 hours (longer in the elderly or those with liver disease)
Propofol:
Next, she left propofol off the list. Propofol is normally administered during surgery at 2mg / kg of body weight. This means that a person weighing 80 kg would typically receive 160 mg of propofol to render them unconscious for their surgery. The protocol for Medical Assistance in Dying is for the patient to be administered 1,000 mg of propofol.
🧠 Primary Region Affected: The Brain
Propofol acts predominantly on the brain to cause:
💤 1. Loss of Consciousness
- Acts on the reticular activating system (RAS), which controls wakefulness.
- Enhances GABA-A receptor activity (inhibitory neurotransmission), leading to deep CNS depression.
🧘♂️ 2. Sedation, Amnesia, and Anxiolysis
- Diminishes activity in:
- Cerebral cortex (awareness, cognition)
- Hippocampus (memory formation)
- Amygdala (emotional responses)
🫁 3. Respiratory Depression
- Suppresses medullary respiratory centers, which control breathing rhythm.
- Can lead to hypoventilation or apnea, especially when given in large doses.
❤️ 4. Cardiovascular Effects
- Reduces systemic vascular resistance, leading to:
- Hypotension
- Bradycardia (in some cases)
- These are indirect effects from brainstem depression and vasodilation.
Remember, the effects occur at the recommended dosages. The MAiD protocol calls for administering far greater doses than what is recommended.
Rocuronium:
Rocuronium is a neuromuscular blocking agent. For surgeries it is usually given at 0.305 mg / kg of body weight. Under the MAiD protocol Rocuronium is administered at 200 mg. Rocuronium is given on a daily basis in most hospitals around the world as it allows intubation of patients to occur with little risk to the patient during the intubation procedure.
🩺 Why Rocuronium Is Used:
- Rapid muscle relaxation for intubation
- Muscle paralysis during general anesthesia for surgery
- Ventilator synchronization in the ICU
🕒 Onset and Duration:
- Onset: ~1–2 minutes (faster with higher doses)
- Duration: ~30–60 minutes depending on dose and patient metabolism
Bupivacaine:
And finally, Bupivacaine is an optional drug that can be administered at a dosage of 500mg total. Bupivacaine is used to induce cardiac arrest. Bupivacaine is never used intravenously during regular medical or surgical procedures as it has a very high risk of inducing cardiac arrest.
| Route | Concentration | Typical Dose | Max Dose (without epinephrine) | Max Dose (with epinephrine) |
|---|---|---|---|---|
| Infiltration | 0.25–0.5% | 100–175 mg total | 175 mg | 225 mg |
| Peripheral Nerve Block | 0.25–0.5% | 100–175 mg (depends on block type) | 175 mg | 225 mg |
| Epidural | 0.25–0.5% | 12.5–25 mg per dose (up to 100 mg total) | 175 mg | 225 mg |
| Spinal | 0.5–0.75% (hyperbaric) | 7.5–15 mg total (small volume) | ~15 mg | N/A |
⚠️ Cautions and Contraindications
- Cardiotoxicity: At high doses or inadvertent IV injection, bupivacaine can cause life-threatening arrhythmias or cardiac arrest.
- CNS toxicity: Early signs may include tinnitus, metallic taste, seizures.
- Not recommended for IV regional anesthesia (e.g., Bier blocks) due to high cardiac risk.
Without respiration or blood circulation, loss of consciousness occurs quickly. The brain is the largest consumer of oxygen in the body. The brain is easily damaged due to a lack of oxygen and will die well before the other organs in the body. And no, the brain cannot sense a lack of oxygen in the blood stream. This is why workers who go into oxygen deficient spaces and die look like they’ve just gone to sleep.
The way the body determines if there is a lack of oxygen in the blood stream is by sensing how much dissolved carbon dioxide there is in the blood stream by sensing a pH change in the blood due to the build up of carbonic acids.
However, the brain is overdosing on Midazolam and Propofol. It can’t sense anything. It isn’t aware of anything. And it will be dead long before the drugs come anywhere near close to wearing off.






